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For example, air pollutants, particularly PM2.5, have been demonstrated to induce a number of different types of programmed cell death, including apoptosis, pyroptosis, necrosis, and ferroptosis

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Fast systemic absorption through the highly vascularized nasal mucosa enables the avoidance of first-pass hepatic metabolism, resulting in relatively consistent PK, even in preterm infants (Table 5) (281)